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Intracellular reactive oxygen species production may cause cellular damage ( Reference Streck, Vieira and Wannmacher 9 ) and disorders of the antioxidant defence system ( Reference Blundell, Jones and Rose 12 ) , demonstrating a mechanistic connection between hyperhomocysteinaemia, oxidative stress and disease

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Observational studies investigating the relationship between anesthesia and dementia have had mixed results, but some studies have shown increased cytotoxicity and build up of amyloid plaque following general anesthesia (2)

Bak JF, Moller N, Schmitz O

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